Boss materials are basically what keep endgame moving in Diablo 4 Season 12. If you want to summon bosses like Grigoire, Varshan, Duriel, or Andariel—especially their tougher versions—you'll need a steady supply of things like Living Steel, Distilled Fear, Exquisite Blood, and Stygian Stones. Since this season leans heavily into masterworking and tougher content, having a good farming routine makes a huge difference. Otherwise, it's easy to burn out just trying to keep up. Helltides are still one of the easiest places to start. They're great for picking up Living Steel and Exquisite Blood, especially if you focus on opening Tortured Gifts of Mysteries chests. Fighting Blood Maidens during these events is also worth it since they reliably drop Exquisite Blood. If you can, run Helltides on Torment difficulty and activate buffs like Tribute of Titans beforehand—it boosts how many materials you get and makes the time feel a lot more rewarding. You can also mix in Legion Events while you're there for some extra drops without going too far out of your way. A lot of players have been spending time in the Undercity of Kurast as well. It's one of those places where you can farm a bit of everything without constantly switching activities. You'll pick up multiple boss materials in a single run, and Stygian Stones drop often enough that you can convert them into whatever you're missing later. It fits nicely between Helltide runs, especially when you want something a bit more consistent. Nightmare Dungeons are still part of the loop too, mainly for Distilled Fear and other supporting materials. Lower-tier speed runs work surprisingly well since you can clear them quickly and stack resources without too much effort. Certain affixes help increase drops, but even regular runs are fine as long as you keep the pace up. With the small quality-of-life improvements this season, they feel smoother to run, which helps when you're doing a lot of them back to back. The real progression comes from chaining boss summons together. You use base materials to summon easier bosses, which then drop items needed for higher-tier ones. It turns into a kind of ladder where each step feeds the next. Once you get into a rhythm, it's a lot more efficient than farming everything separately. Running in a group can speed this up even more, since you can rotate summons and cut down on downtime. Infernal Hordes are another solid option if you want a change of pace. Shorter runs—around six waves—tend to give a good balance of rewards without dragging on too long. You can focus on material-related upgrades during the run and come out with useful resources for your next boss cycle. Some players even use alternate characters to farm extra materials and pass them over, which helps speed things up if you're trying to optimize. If you're trying to keep things efficient, a simple loop works best: start with Helltides to gather your base materials, move into Undercity runs to fill in gaps, then spend everything on boss summons. Convert extra materials when needed and repeat. Builds with strong mobility and area damage make this a lot smoother, but the main thing is keeping the cycle going so you're always progressing instead of stopping to farm one item at a time. As a trusted gaming service platform, U4GM helps players stay up to date with Diablo 4 guides, builds, and in-game details. Visit https://www.u4gm.com/diablo-4/items for the latest deals and services to power up your Diablo 4 experience.